Understanding Blood Group Genetics: MNSs and Kell System Variants

Dec 11, 2025

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This article explores the complexities of blood group systems, focusing on the MNSs blood group and the Kell system. We delve into the genetic underpinnings on chromosome 4 and the co-dominance of the MNSs variants. The significance of antibodies such as anti-M, anti-N, and anti-Kell is discussed, alongside Lewis blood group interactions and their immunological implications. The relationship between blood groups and conditions like muscular dystrophy is examined, providing a comprehensive understanding of blood type inheritance and clinical relevance.

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Understanding Blood Group Genetics: MNSs and Kell System Variants

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Other Blood Groups
S+ s+ S+ s- S- s+ S- s- MNSs • M+ N+ • M+ N- • M- N+ • M- N-

MNSs • MNSs Chromosome 4 • Ns>Ms>MS>NS • MNSs Co dominant
MNSs • S 29 Met • s 29 Ter • Milten berger Hybridof A,B, E glycophorin
MN A IgM • SsB IgG
M + Band 3 Wrb

Antibody • Vicia Graminia Anti N • Ibris Amara Anti M
Lewis

Product of Lewis • Lewis Chromosome19 Fut3 • Se Chromosome19 Fut2 • GI Cells GI Blood RBC
Lewis recipient of H.Pylori • Lewis Null Recurrent Candida
Kell • Kell Chromosome 7 • Allels: K / k Kpa /Kpb Jsa/Jsb • Inheritance: Codominant . Protein: fusion with Kx protein Kx null Mc Load phenotype