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Overview: the roles of transcription and translation in the flow of genetic information

Overview: the roles of transcription and translation in the flow of genetic information. The triplet code. The dictionary of the genetic code. The stages of transcription: initiation, elongation, and termination (Layer 1).

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Overview: the roles of transcription and translation in the flow of genetic information

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  1. Overview: the roles of transcription and translation in the flow of genetic information

  2. The triplet code

  3. The dictionary of the genetic code

  4. The stages of transcription: initiation, elongation, and termination (Layer 1)

  5. The stages of transcription: initiation, elongation, and termination (Layer 2)

  6. The stages of transcription: initiation, elongation, and termination (Layer 3)

  7. The stages of transcription: initiation, elongation, and termination (Layer 4)

  8. Transcription Movie

  9. The structure of transfer RNA (tRNA)

  10. The initiation of translation

  11. The elongation cycle of translation

  12. The termination of translation

  13. Translation Movie

  14. Polyribosomes

  15. Coupled transcription and translation in bacteria

  16. The signal mechanism for targeting proteins to the ER

  17. RNA Modification • 5’ cap • 3’ Poly A tail • Splicing • Exons • Introns

  18. RNA processing; addition of the 5 cap and poly(A) tail

  19. RNA processing: RNA splicing

  20. A summary of transcription and translation in a eukaryotic cell

  21. Categories and consequences of point mutations: Base-pair substitution

  22. Categories and consequences of point mutations: Base-pair insertion or deletion

  23. An English Example THEBOYANDTHEDOGRANFAR THE BOY AND THE DOG RAN FAR Missense: THE BOY AND THE HOG RAN FAR Nonsense: THE BOY AND .

  24. English Example-Frameshift THEBOYANDTHEDOGRANFAR THE BOY AND THE DOG RAN FAR DEletion: THE BOY ADT HED OGR ANF AR Insertion: THE EBO YAN DTH EDO GRA NFA R

  25. Genetic cause of sickle cell disease

  26. The molecular basis of sickle-cell disease: a point mutation

  27. You have a DNA strand with this nucleotide sequence TACCATGGCCGATACGAGGCCCTGAGC What is the other strand?

  28. The Complementary strand would look like this TACCATGGCCGATACGAGGCCCTGAGC ATGGTACCGGCTATGCTCCGGGACTCG

  29. Transcribe it TACCATGGCCGATACGAGGCCCTGAGC *ATGGTACCGGCTATGCTCCGGGACTCG* Using the 2nd strand as a template transcribe a mRNA

  30. Transcribe it TACCATGGCCGATACGAGGCCCTGAGC ATGGTACCGGCTATGCTCCGGGACTCG UACCAUGGCCGAUACGAGGCCCUGAGC

  31. Translate the mRNA you just made ATGGTACCGGCTATGCTCCGGGACTCG UACCAUGGCCGAUACGAGGCCCUGAGC AUG/GCC/GAU/ACG/AGG/CCC/UGA/GC Met-ALA-Asp-Thr-Arg-Pro

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