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Supplementary Figure Legends

This study examines the variance of pDβH activity in three different populations using published data. It presents a genotype-specific variance against mean pDβH activity, emphasizing confidence intervals for observed variances. Additionally, we explore model-based and model-free linkage analyses of pDβH activity on chromosome 19, comparing different Mendelian models under logarithm transformation. The findings provide insights into the genetic architecture of pDβH activity and its relationship with other traits post SNP adjustments, enhancing our understanding of the underlying genetic mechanisms.

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Supplementary Figure Legends

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  1. Supplementary Figure Legends Supplementary Figure 1: The variance of pDH activity plotted against mean pDH activity for three populations, obtained from the table published in Zabetian et al (2001). For each population, the blue profile is the genotype-specific variance vs. the mean of pDH activity at rs1611115, the red straight line connects the estimated mean for the high homozygote and the origin and the vertical lines are the 95% confidence intervals for the observed variances on the assumption of normal distributions. Supplementary figure 2:Model-based linkage analysis of pDβH activity on chromosome 19. The red solid-line profile is the multi-point linkage for pDH activity, with Mendelian additive model under logarithm transformation. The blue dotted-line profile is the multi-point linkage for the new trait (after adjusting for 25 SNPs on chromosome 9), with new Mendelian dominant model under logarithm transformation. Supplementary figure 3:Model-free linkage analysis of pDβH activity on chromosome 19. The red solid-line profile is the linkage for pDH activity under logarithm transformation. The blue dotted-line profile is the linkage for the new trait (after adjusting for 25 SNPs on chromosome 9), under logarithm transformation. Supplementary figure 4:Genome-wide model-based linkage of the new trait formed by adjusting for the 25 SNPs, with an additive model under the square-root transformation.

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