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Mock

Supplementary Fig 1. Mock. NDRG2. A. **. 1.25. Integrin β 6. 1.00. Fold induction. 0.75. PAI-1. 0.50. NDRG2. 0.25. GAPDH. 0.00. Mock. NDRG2. B. Real time PCR.

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Mock

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  1. Supplementary Fig 1 Mock NDRG2 A ** 1.25 Integrin β6 1.00 Fold induction 0.75 PAI-1 0.50 NDRG2 0.25 GAPDH 0.00 Mock NDRG2 B Real time PCR Supplementary Fig 1. NDRG2 attenuated TGF--mediated signaling pathway. (A)Effect of NDRG2 on transcriptional expression of integrin 6 and PAI-1 which are associated with TGF--mediated signaling. (B) The spontaneous SBE activation of 4T1-Mock and 4T1-NDRG2 cells which were transfected with SBE-luciferase construct. **P < 0.01, by t-test.

  2. Supplementary Fig 2 NDRG2 NDRG2 Mock Mock Integrin 6 PAI-1 NDRG2 20 15 15 ** TGF-β1 TGF-β R1 ** 10 10 TGF-β2 TGF-β R2 Relative expression 10 5 5 TGF-β3 TGF-β R3 0 0 0 GAPDH GAPDH M M M N N+T N N+T N N+T B A Supplementary Fig 2. Comparison of gene expression related with TGF- signaling in 4T1-mock and 4T1-NDRG2. (A)mRNA levels of TGF- subtypes and their receptors in 4T1-mock and 4T1-NDRG2 cells. (B) mRNA levels of TGF- target genes, integrin6 and PAI-1, in 4T1-mock and 4T1-NDRG2 treated with recombinant TGF-. M: 4T1-Mock; N: 4T1-NDRG2; N+T: 4T1-NDRG2 treated with TGF-. **P < 0.01, by t-test.

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