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Molecular Characterization of NKCL and PTCL with Emphasis on γδ-T Cell Lineage

This study provides a comprehensive analysis of the median expression levels of various representative transcripts in NK cell (NKCL) and αβ-T cell lymphoproliferative disorders (PTCL), including γδ-ENKTL. The focus is on key genes such as KIR2DL4, CSTW, IL18BP, and others, revealing important insights into the molecular signatures that characterize these malignancies. Understanding the distinctive profiles shows promising avenues for targeted therapies and better patient stratification within these hematological cancers.

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Molecular Characterization of NKCL and PTCL with Emphasis on γδ-T Cell Lineage

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  1. Molecularly defined NKCL Median expression -ENKTL NKCL CT(α)-PTCL Median expression CT(α)-PTCL NKCL -ENKTL -SIGLEP3 -ITAGD -KIR2DL4 -TCR- -KLRC3 -KLRC4 -IL34 -IL18BP -CSTW -CXCL3 -PTCL (NHS) CT(α)-PTCL -PTCL (NHS) CT(α)-PTCL -TCR- -LAT2 -IL2RB -KLRC3 -CD244 -NCR1 -NCAM1 -SH2D1B -SH3BP1 -FCRLB -KIR2DL4 -TRD -CTSW -CTSD -IL10RA -KLRK1 -KLRC2 -KLRC3 -KLRC4 -IKZF2 -PRF1 -GZMA -TGFBRAP1 -KIR2DS5 -IL23A -NKG7 -FCRLB -KLRC2 -PTGER2 -IL23A -SH2DIB(EAT2) -FCRLB -NCAM1(CD56) -NCR1(NK-p46) -CD244 (2B4)) -SH2D3 • CCR7 • ETV1 • NRAS • IK2F1 • RUNX2 • IZKF1 • IL11 Representative transcripts Representative transcripts • CD3D • CD3G • CD4 • CD5 • TCR- • CD6 • CD27 • CD28 • CD226 • CD25 • CD5 -CD5 -CD28 -CD82 -CD27 -CD30 -CADM1 (TSCL1) -CCR7 -CCR9 -CCR10 -MALT1 -IKZF1 -TCR- -MAL -PKIA -TCF4 -IL27RA (NKCL refers only to lymphomas of NK-cell lineage including ENKTL and, ANKL and -T represent two cases of ENKTL with  T-cell lineage) TCR- (median) TCR-α (median) SupplementalFigure 2 (B) (A) Molecularly defined

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