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Osler Institute – Pathology Board Review: Electron Microscopy

Osler Institute – Pathology Board Review: Electron Microscopy. EM of Tumors and Tumor-like Entities. Electron Microscopy - Osler Institute Pathology Board Review. Neoplasms Oncocytoma Salivary gland Parotid Kidney. Electron Microscopy - Osler Institute Pathology Board Review. Neoplasms

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Osler Institute – Pathology Board Review: Electron Microscopy

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  1. Osler Institute – Pathology Board Review: Electron Microscopy EM of Tumors and Tumor-like Entities

  2. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Oncocytoma • Salivary gland • Parotid • Kidney

  3. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Oncocytoma • Pleomorphic mitochondria • Lamelliform (plate like) mitochondrial cristae • Dense bodies in mitochondria

  4. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Plasmacytoma • Nuclei • Marginated heterochromatin • Prominent profiles of rough endoplasmic reticulum • Immunoglobulin inclusions in RER and nucleus

  5. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Renal Cell Carcinoma • (conventional type) • Long microvilli • Glycogen • Lipid droplets

  6. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Renal Cell Carcinoma • Chromophobe Type • Microvesicles • Hale’s colloidal iron positive • Papillary (chromophil) Type • Abundant mitochondria

  7. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Seminoma • Wandering, ropy, nucleolus • Finely dispersed heterochromatin • Inconspicuous organelles • Intercellular junctions

  8. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Squamous cell carcinoma • Desmosomes • Tonofilament bundles

  9. Electron Microscopy - Osler Institute Pathology Board Review Small Round Cell Tumors

  10. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Small Round Cell Tumors • Ewings Sarcoma • Dispersed heterochromatin • Small nucleolus

  11. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Small Round Cell Tumors • Ewings Sarcoma • Large pools of glycogen

  12. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Small Round Cell Tumors • Rhabdomyosarcoma • Actin-myosin filaments with Z-band • Primitive sarcomeres

  13. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Small Round Cell Tumors • Rhabdomyosarcoma • Ribosome-filament complexes • Small primitive junctions • External lamina

  14. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Small Round Cell Tumors • Neuroblastoma • Cell processes • Secretory granules • Microtubules • Neurofilaments

  15. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Small Round Cell Tumors • Lymphoma (Follicular Center Cell) • No cell junctions

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