Survival Analysis of MBZ Treatment on Orthotopic Tumor-Induced Mice
Examining the survival rates of mice with orthotopic tumors treated with MBZ. RNA expression of GLI1, PTCH1, and PTCH2 was assessed. Euthanization details provided.
Survival Analysis of MBZ Treatment on Orthotopic Tumor-Induced Mice
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Presentation Transcript
Figure S1 A B * * GLI1/GAPDH mRNA Survival (%) Vehicle m=61dMBZ m=80d ** Treatment Time (Days) Supplementary Fig S1. (A) Survival of mice with DAOY-derived orthotopic tumors at 25 mg/kg MBZ (n=4) or mock-treated (n=3). One mouse from the mock treatment group did not develop symptoms of a growing brain tumor, and was euthanized after surviving for more than six months. This mouse was not found to have a brain tumor, and was therefore omitted from this analysis. (B) RNA was harvested from untreated and treated tumors and assessed by qRT-PCR for expression of GLI1, PTCH1, and PTCH2.