1 / 8

Cells Interact with their Environment: The Extracellular Matrix

Cells Interact with their Environment: The Extracellular Matrix. What is the extracellular matrix?. Extra (E) cellular (C) matrix (M) Outside/outer of the cell surroundings within which something is contained The part of animal tissue (outside of the cells) that provides

comfort
Télécharger la présentation

Cells Interact with their Environment: The Extracellular Matrix

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Cells Interact with their Environment:The Extracellular Matrix

  2. What is the extracellular matrix? • Extra (E) cellular (C) matrix (M) Outside/outer of the cell surroundings within which something is contained • The part of animal tissue (outside of the cells) that provides __________________________ to the cells contained within. What is the ECM composed of? • _____________________: large polysaccharides with net negative charge, attracting __________ ions, such as ______, which then cause ___________ accumulation, _______________________ • _________: collagen & elastin, which provide ______________ • Cell adhesion proteins: fibronectin, which provides anchor points for cells to ____________ to.

  3. Cell Interaction with the ECM (Migration) • Steps: • 1. Protrusion • 2. Adhesion • 3. Contraction • 4. Release

  4. How might a scientist study cell-ECMinteractions? • What characteristics might a synthetic ECM need • What materials might havethese desired qualities?

  5. What is a polymer? • Poly - mer - Definition: polymers are long-chain molecules consisting of repeating units (called: ______________) which are typically connected by ___________ chemical bonds. • Synthetic Example Polyethylene (PE): CH2=CH2 CH2(CH2CH2)n • Natural Example polysaccharide: Chitosan, randomly distributed D-glucosamine and N-acetyl-D-glucosamine units

  6. Characterization of Polymers • Skeletal structure: • Primary structure: • Homopolymer (1 monomer species) • –A-A-A-A-A-A- • Copolymer (2 or more monomer species) • Random –A-B-A-A-B-A-B • Block –A-A-A-B-B-B- • Alternating –A-B-A-B-A-B Free Crosslinked Linear Branched

  7. Polymer Usage as a Biomaterial • What is a biomaterial? • Examples:

  8. Carbon Ring Numbering

More Related