1 / 4

0.5

1. Fraction Viable. 0.5. rpl6b D (31.6). 0. 0. 20. 40. 60. 80. Age (generations). A. B. 1. Fraction Viable. 0.5. idh2 D (30.3). wt (25.9). wt (25.6). 0. 0. 20. 40. 60. Age (generations). C. D. 1. 1. Fraction Viable. Fraction Viable. 0.5. 0.5. tor1 D (30.6).

Télécharger la présentation

0.5

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. 1 Fraction Viable 0.5 rpl6bD (31.6) 0 0 20 40 60 80 Age (generations) A B 1 Fraction Viable 0.5 idh2D (30.3) wt (25.9) wt (25.6) 0 0 20 40 60 Age (generations) C D 1 1 Fraction Viable Fraction Viable 0.5 0.5 tor1D (30.6) sch9D (40) wt (25.3) wt (25.5) 0 0 0 20 40 60 0 20 40 60 80 Age (generations) Age (generations) E F 1 1 Fraction Viable Fraction Viable 0.5 0.5 idh1D (31.7) sam1D (30.7) wt (28.3) wt (26.5) 0 0 0 20 40 60 80 0 20 40 60 Age (generations) Age (generations)

  2. G H 1 1 Fraction Viable Fraction Viable 0.5 0.5 ypt6D (32.2) inp51D (31.8) wt (27.0) wt (28.5) 0 0 0 20 40 60 80 0 20 40 60 Age (generations) Age (generations) I J 1 1 Fraction Viable Fraction Viable 0.5 0.5 pkh2D (32.1) hse1D (30.5) wt (27.2) wt (25.5) 0 0 0 20 40 60 80 0 20 40 60 Age (generations) Age (generations) K L 1 1 Fraction Viable Fraction Viable 0.5 0.5 pmr1D (34.2) adh1D (33.1) wt (27.4) wt (27.8) 0 0 0 20 40 60 80 0 20 40 60 80 Age (generations) Age (generations)

  3. M N 1 1 Fraction Viable Fraction Viable 0.5 0.5 ygr130cD (30.7) dbp3D (31.5) wt (24.5) wt (24.7) 0 0 0 20 40 60 0 20 40 60 Age (generations) Age (generations) O P 1 1 Fraction Viable Fraction Viable 0.5 0.5 alg12D (31.9) tis11D (32.4) wt (25.7) wt (25.2) 0 0 0 20 40 60 0 20 40 60 Age (generations) Age (generations) Q 1 Fraction Viable 0.5 sis2D (36.2) wt (26.5) 0 0 20 40 60 80 Age (generations)

  4. Figure S1. Mortality curves for conserved aging genes. Replicative life span is significantly extended by deletion of IDH2 (A), RPL6B (B), TOR1 (C), SCH9 (D), SAM1 (E), IDH1 (F), INP51 (G), YPT6 (H), HSE1 (I), PKH2 (J), PMR1 (K), ADH1 (L), YGR130C (M), DBP3 (N), ALG12 (O), TIS11 (P), and SIS2 (Q). Mortality curves for the other conserved aging genes are shown in Figure 1. Curves shown in blue indicate deletion of a gene in the RBH set, while those shown in red indicate deletion of a gene in the RP set. Life span data from both mating types was combined to generate these mortality curves. Mean life spans are given in parentheses in the key of each panel.

More Related