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Proteins PowerPoint Presentation

Proteins

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Proteins

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  1. ……say: ( all ) good things are made lawful for you, so eat of that which they catch for you and mention Allah’s name upon it…… 4-TheTable Spread

  2. Proteins Digestion and absorption

  3. Proteolytic enzymes

  4. Proteolytic enzymes

  5. Classification of Proteases Exopeptidases Polypeptidases Aminopeptidases Carboxypeptidases Tripeptidases Dipeptidases Endopeptidases Pepsin Trypsin Chymotrypsin Elastase

  6. Stomach Digestion of proteins

  7. Stomach • Parietal cells • HCl • Chief cells • Pepsin (endopeptidase)

  8. Acidic and aromatic amino acids H+ Pepsinogen Pepsin

  9. Exocrine pancreas Digestion of proteins

  10. Exocrine pancreas • Bicarbonate • Pancreatic proteases • Zymogens

  11. Activation Enterokinase • Trypsinogen→ Trypsin • Chymotrypsinogen→Chymotrypsin • Proelastase→Elastase • Procarboxypeptidase→ Carboxypeptidase

  12. Arginine and lysine • Trypsin

  13. Acidic and hydrophobic amino acids • Chymotrypsin

  14. Alanine, glycine and serine • Elastase

  15. Hydrophobic and basic amino acids • Carboxypeptidase • Carboxypeptidase A • Carboxypeptidase B

  16. Intestine Digestion of proteins

  17. Intestinal enzymes • Exopeptidases • Brush border • Within the cell • Enterokinase

  18. Intestinal enzymes • Aminopeptidase

  19. Which of the following enzymes is activated through an autocatalytic process? • Enteropeptidase • Proelastase • Pepsinogen

  20. Intestinal brush border Absorption of amino acids

  21. Transport systems • Na Dependent • Neutral • Prolinehydroxyproline • Acidic • Basic and cystine • 2. Na Independent • Facilitated transport

  22. Na+ 2K+ 3Na+

  23. Na+

  24. Na+

  25. Na+

  26. Na+

  27. Na+

  28. Disorders of protein digestion

  29. Disorders of protein digestion • Cystic fibrosis • Cystinuria • Hartnup disease • Kwashiorkor

  30. Cystic fibrosis

  31. Cystic fibrosis • Defect in function of chloride channels in pancreatic secretory ducts • Inspissation of pancreatic exocrine secretions • Eventual obstruction of ducts

  32. Cystic fibrosis • Clinical features • Recurrent infections • Poor growth • Foul smelling bulky stools • Treatment • Commercial enzyme preparations

  33. Hartnup disease • Defect • Autosomal recessive disorder • Transport of neutral amino acids across both intestinal and renal epithelial cells

  34. Hartnup disease Essential Non essential Alanine Serine Tyrosine • Isoleucine • Leucine • Phenylalanine • Threonine • Tryptophan • Valine

  35. Hartnup disease • Clinical features • Asymptomatic • Pallegra like symptoms • Neuropsychiatric • Treatment • Niacin

  36. Cystinuria • Defect in absorption of • Cystine • Ornithine • Arginine • Lysine • Clinical features • Appearance of above mentioned amino acids in urine • Cystine stones • Treatment • Oral hydration

  37. Kwashiorkor • Cause • Deficiency of protein in diet adequate in calories • Clinical features • Muscle wasting • Edema

  38. In hartnup disease there is defect in absorption of aa? • Neutral • Acidic • Basic

  39. THE END

  40. SUPER! Hartnup

  41. Ooooooops! YOU MISSED IT Hartnup

  42. SORRY! Hartnup

  43. WELL DONE! ENZYMES

  44. YOU NEED BETTER CONCEPTS! ENZYMES

  45. YOU MISSED IT! ENZYMES

  46. THE END