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Insulin Bioreactor Design

Insulin Bioreactor Design

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Insulin Bioreactor Design

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  1. Insulin Bioreactor Design CHEE 450 Thursday, March 29

  2. Reactor Considerations • Production of insulin precursor • 5000 kg insulin per year • Assumes 20 % loss due to purification • kLa within 10% of 2088 hr -1 • Prevents oxygen limited reaction • Prevents anaerobic metabolism • Glucose concentration < 0.5 g/L • Prevents formation of ethanol • CSTR configuration • Jacket heat exchanger • Price

  3. How Unit Operates • Substrate feed • Glucose, ammonia, mineral salts • Cellular metabolism of substrate • Extracellular production of insulin • Air sparging for oxygen delivery • Impellers for mixing of nutrients and oxygen

  4. Di 1.3 m HL**= 6.06m HL*= 5.5 m Dt 1.50 m Bioreactor Specifications Total volume = 11.8 m3

  5. Final Design Specifications

  6. Final Design continued….

  7. Companies That Produce Insulin • Sanofi Pasteur • Novonordisk • Eli Lilly • Average cost = $40/100 I.U. or ~$800/kg • Final production cost ~$12/kg precursor • Includes capital and operating costs (minus medium)

  8. Novonordisk Bioreactor

  9. Questions?