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Understanding Effector T Cell Activation and Function in Immunology

This guide explores the activation and role of effector T cells in the immune response, emphasizing the differences between naïve and effector T cell activation. Unlike naïve T cells, effector T cells do not require costimulation and exhibit distinct migration patterns. It discusses the importance of CD45 phosphatase in T cell activation, the involvement of secondary lymphoid tissues, and the mechanisms of cytotoxicity against infected or tumor cells. Key insights into the structure and function of effector T cells, including granule release and the mechanism underlying CTL (Cytotoxic T lymphocyte) killing, are highlighted.

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Understanding Effector T Cell Activation and Function in Immunology

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  1. Reminders • Exam 3- Will be Returned next week. • MC average: 80%

  2. Gaining effector T cell function Effector functions are detected following proliferation of the naïve T cell for ~4-5 days (IL2 induced).

  3. How does the activation of a naïve T cell differ from activation of an effector T cell? • Effector T cells do not require costimulation.

  4. Effector T cells are more easily activated & no longer demonstrate the migration pattern of naïve T cells:

  5. Janeway, p. 342 Fig. 6.24, parham

  6. CD45- phosphatase- Removes P group off of the carboxy terminus of Fyn & Lck thereby activating them. Inhibitory phosphates in red • CD45 RO isoform- associates tightly with TCR complex & Coreceptor than CD45RA.

  7. T Cell Mediated Immunity A closer look at the effector T cells!

  8. Are activated in the 2o lymphoid tissue & migrate to sites of infection. Carry modified lysosomes or granules containing cytotoxic material. Target cells that are infected with intracellular pathogens/ tumor cells. The CD8+ CTL

  9. MTOC- microtubule organizing center

  10. TCR complexes LFA-1 interaction with ICAM1

  11. What happens following the release of the granules?

  12. Mechanism for CTL killing:

  13. Tradition model:

  14. 2nd method: FAS ligands

  15. CAD = Caspase Activatable DNase Janeway T cell Target cell

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