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Gene Expression Analysis of RB15 Mutant and Treated Mouse Models in Various Organs

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This study examines the gene expression profiles of the RB15 mutant and treated mouse models across various organs, including the liver, duodenum, stomach, jejunum, kidney, spleen, heart, colon, lung, and ileum. Using RT-PCR techniques, we analyzed the expression levels of ApoB mRNA in different conditions, finding a statistically significant difference (p = 0.0262) in treated versus untreated samples. This research helps understand the effects of RB15 mutation and treatment on multiple organ systems in a mouse model.

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Gene Expression Analysis of RB15 Mutant and Treated Mouse Models in Various Organs

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  1. (A) Untreated Liver Duodeum Stomach Jejunum Kidney Spleen Heartt Colon Lung Liver Ilium Fat Day 7 RB15 Day 150 RB15 (B) RT-PCR PCR RB15 RB15-mutant RB15 RB15-mutant 1 2 3 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 10 4 RB15-RNA (C) p = 0.0262 Mouse ApoB mRNA/18S RNA ( x 10-5) RB15-mutant Treated RB15-Treated

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