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Supplemental Digital Content 1. 17 Representative graph s showing progesterone levels in blood ,and the detection of initial viremia (x). Macaque IDs are indicated (top left). Some of the points are negative because day 1 of those specific cycles could not be determined. 96PO17. 7000. 6000.
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Supplemental Digital Content 1 17 Representative graph s showing progesterone levels in blood ,and the detection of initial viremia (x). Macaque IDs are indicated (top left). Some of the points are negative because day 1 of those specific cycles could not be determined.
96PO17 7000 6000 5000 4000 3000 2000 1000 0 -27 -22 -15 -8 -4 1 3 7 15 21 28 x progesterone levels (pg/mL) day of menstrual cycle 11000 Pra-2 10000 9000 8000 7000 6000 progesterone levels (pg/mL) x 5000 4000 3000 2000 1000 0 -11 -7 -4 1 4 15 18 25 29 1 5 12 21 1 day of menstrual cycle
96PO26 10000 8000 6000 Progesterone levels (pg/mL) 4000 2000 0 -33 -28 -21 -14 -11 -6 -4 1 4 9 11 15 18 22 4000 TD6 3000 2000 1000 0 -28 -21 -14 1 8 15 1 x day of menstrual cycle x progesterone levels (pg/mL) day of menstrual cycle
20000 PGB2 17500 15000 12500 10000 7500 5000 2500 0 -14 -7 1 5 8 22 1 8 7000 PTD2 6000 5000 4000 3000 2000 1000 0 -7 1 8 12 15 1 12 19 x Progesterone levels (pg/mL) day of menstrual cycle x Progesterone levels (pg/mL) day of menstrual cycle
8000 FH3 7000 6000 5000 4000 3000 2000 1000 0 7000 -21 -14 1 4 8 10 15 18 22 25 1 4 8 15 22 30 1 96PO78 6000 5000 4000 3000 2000 1000 0 -21 -18 -14 -12 -7 -4 1 4 8 11 15 22 29 37 44 Progesterone levels (pg/mL) x day of menstrual cycle Progesterone levels (pg/mL) x day of menstrual cycle Remark: Post-infection, this macaque did not exhibit progesterone peaks during the measurement period. This could be related to the study stresses of frequent anesthesia, animal handling, and acute SHIV infection.
16000 PDe-2 14000 12000 10000 8000 PMc-2 6000 20000 4000 17500 15000 2000 12500 0 -4 1 4 8 11 15 18 22 25 29 32 36 1 5 12 19 26 10000 7500 5000 2500 0 -4 1 5 8 15 19 22 26 29 1 5 8 12 15 20 23 29 1 Progesterone levels (pg/mL) x day of menstrual cycle Progesterone levels (pg/mL) x day of menstrual cycle
6000 PSc-2 5000 6000 4000 PVr-1 5000 3000 4000 2000 3000 1000 2000 0 -6 1 4 8 11 15 18 22 25 29 1 5 8 12 15 26 1 1000 0 -7 -4 1 4 8 11 15 18 22 25 32 8 46 53 60 Progesterone levels (pg/mL) x day of menstrual cycle Progesterone levels (pg/mL) x day of menstrual cycle Remark: Post-infection, this macaque did not exhibit progesterone peaks during the measurement period. This could be related to the study stresses of frequent anesthesia, animal handling, and acute SHIV infection.
10000 P8X 9000 8000 7000 6000 5000 4000 3000 2000 7000 1000 PYa-2 6000 0 -21 -14 -7 1 8 14 22 29 36 1 9 15 22 28 1 14 43 5000 4000 3000 2000 1000 0 -7 -4 1 4 8 11 15 18 22 25 32 39 46 53 60 68 x Progesterone levels (pg/mL) day of menstrual cycle Progesterone levels (pg/mL) x day of menstrual cycle Remark: Post-infection, this macaque did not exhibit progesterone peaks. This could be related to the study stresses of frequent anesthesia, animal handling, and acute SHIV infection.
2000 15000 303 PZu-1 1750 12500 1500 10000 1250 1000 7500 750 5000 500 2500 250 0 0 -10 -7 -7 1 8 15 1 21 5 1 8 8 15 12 22 15 30 1 22 8 14 29 29 1 36 43 30 37 43 50 50 1 1 9 x Progesterone levels (pg/mL) day of menstrual cycle Remark: Post-infection, this macaque experienced a delayed progesterone peak. This could be related to the study stresses of frequent anesthesia, animal handling, and acute SHIV infection. first virus challenge x Progesterone levels (pg/mL) day of menstrual cycle
9000 FF2 8000 7000 6000 5000 4000 3000 2000 1000 0 -21 -14 -7 1 8 14 22 1 8 15 23 1 8 14 29 1 30 x Progesterone levels (pg/mL) day of menstrual cycle
