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Associations of Alpha-Fetoprotein and Human Chorionic Gonadotropin with Tumors and Inclusion Bodies

High levels of alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) are significant biomarkers in various tumors, including endodermal sinus tumors, choriocarcinomas, germinomas, pineoblastomas, and teratomas. Additionally, distinctive viral inclusions such as Cowdry B bodies are seen in herpes encephalitis. Further, Wilson's disease is characterized by features like decreased serum ceruloplasmin and copper levels, along with distinctive neurological manifestations and genetic mutations. Understanding these associations enhances diagnostic accuracy and patient management.

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Associations of Alpha-Fetoprotein and Human Chorionic Gonadotropin with Tumors and Inclusion Bodies

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  1. Citow ReviewPathology 8/2/13

  2. High levels of alpha-fetoprotein are associated with • Endodermal sinus tumors • Choriocarcinomas • Germinomas • Pineoblastomas • Teratomas

  3. High levels of alpha-fetoprotein are associated with • Endodermal sinus tumors • Choriocarcinomas • Germinomas • Pineoblastomas • Teratomas

  4. High levels of human chorionic gonadotropin are seen in • Choriocarcinoma • Embyronal carcinoma • Endodermal sinus tumor • Germinoma • Teratoma

  5. High levels of human chorionic gonadotropin are seen in • Choriocarcinoma • Embyronal carcinoma • Endodermal sinus tumor • Germinoma • Teratoma

  6. Viral inclusions seen in herpes encephalitis are • Basophilic • Called Cowdry B bodies • Found in neurons only • Intranuclear • Only evident several weeks after infection

  7. Viral inclusions seen in herpes encephalitis are • Basophilic • Called Cowdry B bodies • Found in neurons only • Intranuclear • Only evident several weeks after infection

  8. Inclusion Bodies (Alzheimer’s) (CMV, Herpes, SSPE) (Polio) (Pick’s disease) (Parkinsons, Lewy body dis) (rabies) (myoclonic epilepsy) (ALS)

  9. Cowdry A Inclusions

  10. Each of the following is characteristic of Wilson’s disease except • Alzheimer’s type II astrocytes • Atrophy & brownish discoloration of globuspallidus & putamen • Autosomal dominant • Decreased serum ceruloplasmin • Decreased serum copper

  11. Each of the following is characteristic of Wilson’s disease except • Alzheimer’s type II astrocytes • Atrophy & brownish discoloration of globuspallidus & putamen • Autosomal dominant • Decreased serum ceruloplasmin • Decreased serum copper

  12. Wilson’s Disease • Mutation in ATP7B gene (ch. 13) • ATPase transporter that incorporates copper into ceruloplasmin • Low ceruloplasmin, low copper • Alzheimer type II astrocytes • Abnormal LFTs • MRI: hyperintense BG on T2 • Keiser Fleischer rings • Renal tubular acidosis • Cardiomyopathy

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