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Impact of GABRA5 Knockdown on QHii066-Induced Cell Viability Changes in Medulloblastoma

This research examines the effects of a stable GABRA5 knockdown on the viability of medulloblastoma cells following treatment with QHii066. In Figure S1, GABRA5 knockdown is shown to mitigate the decrease in cell viability caused by QHii066. Figure S2 indicates that QHii066 has minimal effects on normal human neural stem cells compared to the patient-derived MB002 medulloblastoma cell line. Figure S3 details the kinetics of QHii066's growth inhibition in various medulloblastoma cell lines, while Figure S4 demonstrates that diazepam binding inhibitor (DBI) can block QHii066's effects on cell viability.

natasha-delis
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Impact of GABRA5 Knockdown on QHii066-Induced Cell Viability Changes in Medulloblastoma

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  1. Figure S1 - Stable knockdown of GABRA5 mitigates QHii066-mediated decrease in cell viability.

  2. Figure S2 - QHii066 has minimal effect on normal human neural stem cells (SVZ) in comparison to patient-derived MB002 medulloblastoma cell line.

  3. Figure S3 - Kinetics of QHii066 growth inhibition in Group 3 medulloblastoma cells (MB002 left panel, D425 and D283 right panel).

  4. Figure S4 – Diazepam binding inhibitor (DBI) blocks effect of QHii066 on medulloblastoma cell viability.

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