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Development of a Micro-engineered Multispectral MRI Contrast Agent for Enhanced Imaging

This project focuses on the micro-fabrication of a novel MRI contrast agent that offers new opportunities for dynamic imaging. Our enhanced contrast agent aims to provide amplified signals enabling the detection of critical parameters such as temperature, pH, and specific enzymes. This endeavor utilizes advanced photolithography and etching processes to create micro-sized particles. Implementing optimized material characterization techniques and utilizing MRI validation, we explore the magnetic properties of iron and iron oxide to revolutionize MRI technology while ensuring safety and reduced radiation exposure.

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Development of a Micro-engineered Multispectral MRI Contrast Agent for Enhanced Imaging

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  1. Amr Aly Maggie Cox, Rachel Horenstien Technical Advisor: Xin Zhang, Xiaoning Wang BME Advisor: Mark Grinstaff Micro-engineered multispectral MRI Contrast Agent

  2. Motivation • Micro-fabrication of Magnetic Resonance Imaging (MRI) Contrast Agent Particle. • Offer new amplified signals that can be captured by a MRI scanner • More dynamic contrast agent • Detect Temperature, pH and the presence of certain enzymes.

  3. Magnetic Resonance Imaging (MRI) • Magnetic field (B0) is applied along the Z-axis. • Radio frequency (B1) at the Larmour resonant frequency (ω=γB). • Magnetization becomes perpendicular to the Z-axis. • Radio frequency is stopped • Protons’ magnetization relaxes. • T1 & T2 time constants. • Gradient magnets used for spatial encoding. B0=const z y x B1(ω0t)

  4. MRI Advantages & Current Technology • No X-ray exposure, less radiation. • No specific imaging plane such as CT. • Multi view imaging. • Current Contrast Agents: • T1 Altering • Gadolinium • Brightens the image. • T2 Altering • Superparamagnetic (ex iron oxide) • Darkens the image

  5. Specific Aims • Material characterization • Magnetic properties of iron/iron oxide • X-ray Diffraction Analysis • Optimize a fabrication process • Photolithography of mask design • Thin film deposition (e-beam) • Etching of iron/iron oxide & Polyimide • (RIE) • O2 Plasma • Apply the developed fabrication process to the micro-sized particle • Double disk geometry • Magnetic Resonance Imaging (MRI) testing and validation

  6. Design & Methods • Double disk Geometry • Photolithography process • Fabrication of Mask • Electron Beam Lithography (e-beam)

  7. Design & Methods cont. • Reactive Ion Etching • Iron/iron oxide etching • O2 Plasma • Polyimide etching • Use O2 radicals to make etching isotropic • MRI Testing & Validation • 11.7 T MRI

  8. Preliminary Results • Mask Design for Photolithography designed in AutoCAD • Fabricated out of Chromium & glass • Squares have different particle densities

  9. Budget & Project Management Budget: Wafer: $20/wafer (4 inches) and $10/wafer (2 inches) will need 25 wafers. Polyimide: $600/bottle (250g), Shelf life is 6 months, will need 1 bottle. Iron pellet: $120/bottle (100g), will need 1 bottle. Iron oxide pellet: $150/bottle (100g), will need 1 bottle. SQUID machine (magnetometer) at Massachusetts Institute of Technology (MIT): $60/hour Total: $2,200 Project Management Schedule Aim/Task December January February March April May Material Characterization XRD ----------------- SQUID ----------------Fabrication Process Etching (iron/iron oxide) ------------------ Etching (polyimide) -------------------Whole particle fabrication ---------------------------------------------------MRI Validation -----------

  10. Thank you for your time Questions?

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