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Explore the prevalence of depression since World War II, various types of depressions, history of antidepressants, major depression traits, and the consequences of failing to achieve remission. Learn about the physiological effects of depression on brain structures and cognitive functions.
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Prevalence 1) Is depression more prevalent now? Prevalence since world war II: Increased by a)25% b)50% c)100%
Types of Depression 2) How many types of Depressions are known to clinicians? a) 2 types b) 8 types c) Infinite number of types
History of Antidepressants 3) Safe antidepressants have been available for more than: a) 100 years b) 75 years c) 50 years
Major Depression –What is it? 4) Major depression is mainly: a) a functional "mental illness” b) a physical disease c) A body-mind illness
Failure to Achieve Remission: Consequences brain changes chronicity suicide attempts higher relapse rates Failure to Achieve Remission • inter-episode • duration medical comorbidity mortality # of chronic depressive episodes use of medical services and disability benefits impairment in work and relationships McIntyre. J Clin Psych 2010;71:16-20; Trivedi. J Clin Psychiatry 2009;70:26-31; Gradin, Pomi. J Biol Phys 2008;34:107-20.
Physiological Consequences Failure to Achieve Remission: Brain Structural Changes Cognitive impairment and maintenance of depressed mood in MDD may be related to atrophy and altered function of these brain structures • Hippocampal atrophy • Frontal cortex atrophy • Glial cell loss prefrontal cortex • Amygdala hyperactivity Campbell & MacQueen. J Psychiatry Neurosci 2004; 29: 417-26. McKinnon et al. J Psychiatry Neurosci 2009; 34: 41-54.