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Mechanistic Insights into Bleomycin-Induced Lung Injury: A Comparative Study of WT and DKO Models

This study investigates the differential responses of wild-type (WT) and double knockout (DKO) mouse models to bleomycin-induced lung injury. Using fluorescent tagging (FITC, APC, PE), we analyze the expression of key markers SP-C and AQP-5 at day 21 post-treatment. Flow cytometry was employed to assess immune cell populations, including GR-1, F4/80, CD45, CD19, and CD3. Our findings provide insight into the cellular and molecular mechanisms underlying lung fibrosis and assess the roles of oxidative stress (NOX) in mediating damage and repair processes.

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Mechanistic Insights into Bleomycin-Induced Lung Injury: A Comparative Study of WT and DKO Models

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  1. WT saline d21 WT bleo d21 NOX saline d21 WT bleo d21 NOX bleo d21 SP-C FITC SP-C FITC SP-C FITC WT saline d21 NOX saline d21 NOX bleo d21 AQP-5 FITC AQP-5 FITC DKO saline d21 DKO bleo d21 DKO saline d21 DKO bleo d21 AQP-5 FITC Fig. S1

  2. A. WT bleo B. NOX bleo C. DKO bleo GR-1 FITC F4/80 APC D. WT bleo E. WT bleo CD45 FITC CD19 Per CP CD3 APC B220 PE Fig.S2

  3. BrdU SP-C Fig. S3

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