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This study examines the time course of mean arterial pressure (MAP), albuminuria, and kidney injury in C57BL/6 and CD-1 mice following a reduction in renal mass (5/6 nephrectomy, 5/6 Nx) and treatments with deoxycorticosterone acetate (DOCA) and hydralazine. While DOCA-salt treatment resulted in elevated MAP and modest albuminuria without increasing kidney injury, hydralazine led to reduced MAP but also showed limited impact on kidney injury markers. Statistical significance is noted for various comparisons between treatment groups.
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Supplemental Figure 3 Time course of mean arterial pressure, albuminuria, and kidney injury after reduction in renal mass and treatment of C57BL/6 mice with deoxycorticosterone acetate + saline drinking water (DOCA) or treatment of CD-1 mice with hydralazine C57BL/6 mice treated with DOCA-salt (with saline drinking water) after 5/6 Nx (5/6 Nx) or sham surgery (sham) had higher MAP than controls with saline drinking water only (NSS oral) (A, B, left panel); however DOCA-salt resulted in modest albuminuria (C, left panel) and did not increase kidney injury, as measured by serum creatinine (D, left panel). CD-1 mice treated with hydralazine (Hyd) in drinking water after 5/6 Nx (5/6 Nx) or sham surgery (sham) had lower MAP than controls with drinking water only (A, B, right panel); however hydralazine had modest decreases in albuminuria (C, right panel) and did not decrease kidney injury, as measured by serum creatinine (D, right panel). †, P<0.005 vs baseline in each group; ††, P<0.05 vs baseline in each group; *, P<0.005 5/6 Nx with drug administration vs 5/6 Nx control; **, P<0.05 5/6 Nx with drug administration vs 5/6 Nx control; #, P<0.005 sham with drug administration vs sham control; ##, P<0.05 sham with drug administration vs sham control.
