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Suppl Fig. 1a The clinical protocol is shown schematically.

Suppl Fig. 1a The clinical protocol is shown schematically. . Screened for eligibility ( n = 19 ). Excluded ( n = 5 )  Not meeting inclusion criteria ( n = 5 )  Declined to participate ( n = 0 )  Died prior to enrolment ( n = 0 ). Enrolled ( n=14). Randomized to Arm 1 ( n=7)

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Suppl Fig. 1a The clinical protocol is shown schematically.

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  1. Suppl Fig. 1a The clinical protocol is shown schematically.

  2. Screened for eligibility (n=19) Excluded (n=5) Not meeting inclusion criteria (n=5)  Declined to participate (n=0) Died prior to enrolment (n=0) Enrolled (n=14) Randomized to Arm 1(n=7) Removed from study prior to vaccination (n=2) - Disease progression during vaccine production (n=1) - Developed dermatomyositis (n=1) Randomized to Arm 2(n=7) Removed from study prior to vaccination (n=1) - Developed active lung infection (n=1) Received any vaccines (n=5) Recurred after 2 vaccinations (n=1) Received any vaccines (n=6) Recurred after 1 vaccination (n=1) • Included in analysis (n=5) • Included in analysis (n=5) Suppl Fig. 1b The CONSORT diagram of the study enrollment.

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