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Novel Mechanisms of RNAi-Mediated Gene Regulation and Tumorigenesis in Hepatocytes

Explore the impact of RNA interference (RNAi) on gene regulation in hepatocytes and its role in tumorigenesis. Investigate the effects of RNAi stability and transduction on cell behavior and viability.

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Novel Mechanisms of RNAi-Mediated Gene Regulation and Tumorigenesis in Hepatocytes

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  1. 1x1012 (1x104 / Hepatocyte) 2x1011 (2x103 / Hepatocyte) 5x1010 (5x102 / Hepatocyte) 2x1010 (2x102 / Hepatocyte) U6 -- U6 -- AH -- S25 U6 -- U6 -- AH -- S25 H1 -- FATP U6 -- U6 -- H19 p53 S25 H25 H19 S19 L29 p53 S25 H25 H19 S19 L29 p53 S25 H25 wt wt wt wt wt wt wt wt wt ON OFF HBV HBV OFF HBV HBV OFF OFF ON hAAT ON hAAT ON Lethality Transient RNAi Complete, stable RNAi Lethality Partial, stable RNAi Complete, stable RNAi Complete, stable RNAi Transient transduction Tumorigenesis Stable transduction Suppl. Fig S1

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