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Analysis of Gene Expression Correlation with Sensitivity and Specificity in CLL

This study explores the relationship between low and high gene expression levels in chronic lymphocytic leukemia (CLL) and their impact on sensitivity (True Positive Fraction) and specificity (False Positive Fraction). The results indicate a significant difference in expression levels, with high expression correlating with improved sensitivity and low expression linked to reduced specificity. Statistically significant findings (P<0.001) provide insights into potential biomarkers for prognosis and treatment strategies in CLL.

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Analysis of Gene Expression Correlation with Sensitivity and Specificity in CLL

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  1. Low expression High expression 1.0 0.75 8 3 1 2 10 7 9 11 0.5 4 12 14 Sensitvity (TPF) 5 13 NBC-Hst 0.25 NBC-Sst FL 6 CLL 0 0.25 0.5 0.75 1.0 1-Specificity (FPF) CLL FL High expression 9 2 P<0.001 9 Low expression 0

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