Survival Analysis of LysMCre/iDTR Mice After Myocardial Infarction

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In this study, we investigated the mortality rates of LysMCre/iDTR mice subjected to myocardial infarction (MI). Our findings indicate that there was no significant difference in survival between LysMCre/iDTR mice with monocyte/macrophage genetic ablation (injected with diphtheriatoxin at 75%) and control groups, which included both LysMCre/iDTR mice injected with PBS (100%) and WT mice injected with diphtheriatoxin (67%). These results suggest that the absence of monocytes/macrophages does not impact survival post-MI in this model.

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May 06, 2026

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Survival Analysis of LysMCre/iDTR Mice After Myocardial Infarction

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Supp. Figure1. Suppl Fig. 1. Mortality of LysMCre/iDTR mice after MI. Survival was not different in animals with genetic ablation of monocytes/ macrophages (LysMCre/ iDTR mice injected with diptheriatoxin, 75%) when compared to control mice (LysMCre/ iDTR mice injected with PBS (100%) or WT mice injected with diphteriatoxin (67%)).