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Gene Expression Analysis of CD4+ T Cell Subtypes in Response to Cytokine Stimuli

This study examines the mRNA expression levels of various CD4+ T cell subtypes, specifically Th0, Th1, Th2, and Th17, in response to different cytokines such as IL-6, IL-21, and IL-4. We focus on the regulatory roles of transcription factors like T-bet, GATA3, and AhR in modulating the immune response. Our findings reveal significant differences in mRNA levels relating to FoxP3, indicative of T regulatory cell function. This research enhances understanding of T cell plasticity and the impact of the immunological environment on their differentiation.

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Gene Expression Analysis of CD4+ T Cell Subtypes in Response to Cytokine Stimuli

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  1. 250 200 150 100 50 0 Th0 Th1 Th2 Liver Th17-2 Th17-1 Th17-3 Tbet 400 GATA3 300 200 400 100 300 0 200 100 0 Suppl Figure 1 a b c AhR FoxP3 AhR 1000 15 mRNA level to HPRT (x10-3) mRNA level to HPRT (x10-3) % positive CD4+ cells 800 10 600 400 5 200 0 0 nTreg B6 iTreg Th17 Ahrko Th0 + IL-6 d IL-21 IL-4 IFNg 400 20000 7000 6000 Ctrl 300 15000 5000 4000 FICZ 200 10000 3000 2000 5000 100 1000 0 0 0 iTreg iTreg iTreg Th17 Th17 Th17 Th2 Th2 Th0 Th0 Th1 Th1 Th1 Th2 Th0 mRNA level to HPRT (x10-3) FoxP3 400 300 200 100 0 iTreg iTreg iTreg Th17 Th17 Th17 Th0 Th1 Th0 Th1 Th1 Th2 Th0 Th2 Th2

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