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Immunoblot Analysis of Effector Proteins in PDTX Tumors Treated with TAK-733

This figure presents the immunoblot analysis of effector proteins from patient-derived tumor xenograft (PDTX) mice treated with TAK-733 compared to vehicle controls. The proteins evaluated include phosphorylated S6 (pS6), AKT (pAKT), ERK (pERK), along with α-tubulin as a loading control. The analysis aims to elucidate the response to TAK-733 treatment concerning BRAF status, specifically focusing on tumors harboring the V600E mutation. The findings may offer insights into the mechanistic action of TAK-733 in tumor biology.

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Immunoblot Analysis of Effector Proteins in PDTX Tumors Treated with TAK-733

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  1. Suppl Figure 5 MB947 MB1337 MB1547 Immunoblot of Effector Proteins in Tumors from PDTX Mice Treated with TAK-733 TAK-733 vehicle S6 vehicle vehicle TAK-733 TAK-733 pS6 AKT pAKT ERK pERK 1/2 α-tubulin S TGI Response R S WT BRAF Status V600E V600E

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