1 / 6

Dose-Response Analysis of Nitric Oxide Modulation in Hypoxic and Normoxic Rat Models

This study presents a series of supplementary figures illustrating the dose-response effects of nitric oxide (NO) modulation in both hypoxic and normoxic conditions. Baseline measurements and post-treatment assessments are provided for various groups, including control (SHAM), non-selective NOS inhibitor (SEITU), norepinephrine (NEPI), and different scavengers (POE-Hb and C-PTIO). The experimental setup involved a range of doses and multiple groups, with statistical significance indicated by p-values. Results support understanding the physiological responses to NO modulation in a controlled animal model.

shasta
Télécharger la présentation

Dose-Response Analysis of Nitric Oxide Modulation in Hypoxic and Normoxic Rat Models

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Suppl Figure 1.

  2. Supplementary figure S1: Dose-response curves BL: baseline measurement; H/N: measurement after randomisation to hypoxia or normoxia. Open symbols represent normoxic rats, closed symbols are hypoxic rats. SHAM: normoxic and hypoxic control groups; SEITU: non-selective NOS inhibitor S-ethylisothiourea group; NEPI: norepinephrine group; POE-Hb: haem-based NO scavenger pyridoxylatedhaemoglobin poly-oxoethylene group; C-PTIO: organic NO scavenger 2-(4- carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide group; NaNO2: sodium nitrite group. N=4 animals per group.

  3. Suppl Figure 2.

  4. Supplementary figure S2: Dose-response to L-NAME BL: baseline measurement; H/N: measurement after randomisation to hypoxia or normoxia. Open symbols represent normoxic rats, closed symbols are hypoxic rats. LNAME: N (G)-nitro-L-arginine methyl ester. N=3 animals per group.

  5. Suppl Figure 3.

  6. Supplementary figure S3: Haemodynamic effects of NO scavenging after hypoxia and NOS inhibition and after hypoxia, NOS inhibition and nitrite administration BL: baseline measurement; SEITU: non-selective NOS inhibitor S-ethyl-isothiourea; NaNO2: sodium nitrite; POE-Hb: haem-based NO scavenger pyridoxylatedhaemoglobin poly-oxoethylene. *p<0.05 vs baseline; #p<0.05 vs previous step. N=6 animals per group.

More Related