1 / 4

caspase 14, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.1 The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into an a2b2 tetramer to form the active enzyme. Caspase-14 has a conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis.

Allen339
Télécharger la présentation

caspase 14, apoptosis-related cysteine peptidase

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CASP14 caspase 14, apoptosis-related cysteine peptidase BackgroundCaspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.1 The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into an a2b2 tetramer to form the active enzyme. Caspase-14 has a conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis. SynonymsCASP14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis related cysteine protease; caspase-14; apoptosis related cysteine protease; MGC119078; MGC119079; MICE; CASP-14; apoptosis-related cysteine protease; caspase 14, apoptosis-rel Recombinant Proteins Cell & Tissue Lysates

  2. Cat.# Product name Source (Host) Species Tag Price CASP14-0417H Recombinant Human CASP14 Protein, GST-Tagged Wheat Germ Human GST +Inquiry CASP14-1168H Recombinant Human CASP14, His tagged E. coli Human His+Inquiry CASP14-470H Recombinant Human CASP14 Protein, His-tagged E. coli Human His+Inquiry CASP14-2750M Recombinant Mouse CASP14 Protein Mammalian Cells Mouse His+Inquiry Casp14-690M Recombinant Mouse Casp14 Protein, His/GST-tagged E. coli Mouse His/GST +Inquiry Casp14-691M Recombinant Mouse Casp14 Protein, His/GST-tagged E. coli Mouse His/GST +Inquiry Casp14-692R Recombinant Rat Casp14 Protein, His-tagged E. coli Rat His+Inquiry CASP14-3803C Recombinant Chicken CASP14 Mammalian Cells Chicken His+Inquiry Protein Function CASP14 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, protein binding. Some of the functions are cooperated with other proteins, some of

  3. the functions could acted by CASP14 itself. We selected most functions CASP14 had, and list some proteins which have the same functions with CASP14. You can find most of the proteins on our site. FunctionRelated Protein Function cysteine-type endopeptidase activityRelated Protein CASP3B; USP48; USP10; USP43A; USP13; CTSC; CTSL2; CASPB; CTSS; USP19 Function cysteine-type endopeptidase activity involved in apoptotic signaling pathwayRelated Protein CASP9; CASP8L1; CASP2; CFLARA; CASP10; CASP8; CASP14; CFLAR Function protein bindingRelated Protein GABARAP; COMMD6; TNIP2; ALX1; NR1H4; NFS1; ARNTL2; CDK15; IFT27; PAX2 Interacting Protein CASP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP14. MEOX2; PSAP; PRSS3; USP53; OTUB1; PRKAB1; CFTR; CD81 CASP14 Related Articles

  4. Ashokkumar, C; Sun, Q; et al. Antithymocyte Globulin Facilitates Alloreactive T-cell Apoptosis by Means of Caspase-3: Potential Implications for Monitoring Rejection-Free Outcomes. TRANSPLANTATION 99:164-170(2015). Younesi, V; Nejatollahi, F; et al. Induction of anti-proliferative and apoptotic effects by anti-IL-25 receptor single chain antibodies in breast cancer cells. INTERNATIONAL IMMUNOPHARMACOLOGY 23:624-632(2014).

More Related