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Supplementary figure 3

raSIRP  RIKQKKAKGSTSSTRLHE P EKNAREITQIQDTNDINDIT Y ADLNL P KEKK P A P RV P E P NNHTE Y ASIETGKL P R P EDTLT Y ADLDMVHLNR--AQ P T P K P E P SFSE Y ASVQVQRK 509

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Supplementary figure 3

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  1. raSIRPRIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRVPEPNNHTEYASIETGKLPRPEDTLTYADLDMVHLNR--AQPTPKPEPSFSEYASVQVQRK 509 muSIRPRIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRAPEPNNHTEYASIETGKVPRPEDTLTYADLDMVHLNR--AQPAPKPEPSFSEYASVQVQRK 509 huSIRP1 RIRQKKAQGSTSSTRLHEPEKNAREIT--QDT---NDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK 503 **:****:******************* *** ************ *****:..***********:*. * .**************** **:*************** ** Supplementary figure 3 Supplementary Figure 3. Alignment of the cytoplasmic SIRP protein sequences. Alignments were performed using the ClustalW algorithm (version 1.82) employing the following sequences: rat SHPS-1 (gi_6671640), mouse SHPS-1 (gi_1777354), and human SIRP1 (gi_2052056). The two proline-rich regions are overlined and the tyrosine and proline residues are highlighted in blue and red, respectively. The proline residues that, at least in case of the human SIRP1, are dispensable for JAK2 binding (42) are indicated by arrows.

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