1 / 3

Advancing Renal Research: Molecular Insights and Clinical Perspectives

Explore renal biopsy microdissection, transcriptomics, mRNA bioinformatics, RT-PCR, functional studies, and clinical insights in chronic kidney disease progression, apoptosis, inflammation, and hyperglycemia.

duane
Télécharger la présentation

Advancing Renal Research: Molecular Insights and Clinical Perspectives

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Renal biopsy Microdisection of tubulointerstitial and glomerular tissue Transcriptomics: mRNA Bioinformatics: selection of candidate genes RT-PCR: mRNA expression confirmation Inmunohistochemistry: protein expression localization/confirmation Functional studies in cultured cells Functional studies in animal models Clinical studies Figure 1

  2. Osteoprotegerin TRAIL 14-3,3 eta CD74 GG2-1 Osteopontin Caspase 1 EIF4G2 TIA1 Clusterin STAT1 Tubulin-beta NRIF3 EMP3 APP DOCK1 Fas LOXL2 Osteoprotegerin MAPT Apolipoprotein E GADD45A PKC,zeta Sphingosine kinase 2 Prostaglandin E R-3 Cell death TRAIL NF-kB GG2-1 Figure 2 A) B) *

  3. Figure 3 OPG Progression of chronic kidney disease Parenchymal renal cellapoptosis TRAIL Inflammation Hyperglycemia

More Related