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Investigation of mRNA Expression of Key Inflammatory Markers and Extracellular Matrix Proteins

This study examines the relative mRNA expression levels of significant inflammatory markers and extracellular matrix proteins, including NLRP-3, IL-1β, ASC, TNF-α, TIMP-1, and MMP-9, in wild-type and Atp7b-/- mice. Utilizing various age groups, we analyzed gene expression patterns relative to β-actin as a reference. Our findings highlight the role of TNF-R1 and α-SMA in regulating inflammatory responses and tissue remodeling in the context of metabolic dysfunction. This comprehensive analysis serves to further elucidate the molecular pathways involved in inflammation and tissue repair.

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Investigation of mRNA Expression of Key Inflammatory Markers and Extracellular Matrix Proteins

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  1. a c b a c NLRP-3 IL-1β ASC TNF-α TIMP-1 MMP-9 A 5.0 4.5 4.0 3.5 3.0 relative mRNA expression 2.5 2.0 1.5 1.0 0.5 0 wild type Atp7b-/- B wild type Atp7b-/- kD 10 13 15 23 11 11 24 24 age (months) 55 TNF-R1 α-SMA 43 25 LCN2 TIMP-1 23 β-actin 42 Suppl. Figure 1

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