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Therapeutic Potential of Secretases in Alzheimer's Disease: Insights from De Strooper et al. (2010)

This article by De Strooper et al. (2010) explores the role of secretases, enzymes linked to the processing of amyloid precursor protein (APP), in the pathology of Alzheimer's disease. The authors review the mechanisms by which secretases contribute to amyloid-beta production, highlighting their potential as therapeutic targets. Understanding secretase activity is crucial for developing new treatments aimed at slowing or halting Alzheimer's progression. The paper provides a comprehensive overview of the biochemical pathways involved and discusses emerging therapeutic strategies.

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Therapeutic Potential of Secretases in Alzheimer's Disease: Insights from De Strooper et al. (2010)

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  1. Figure 1 Processing of APP by the secretases De Strooper, B. et al.(2010) The secretases: enzymes with therapeutic potential in Alzheimer disease Nat. Rev. Neurol. doi:10.1038/nrneurol.2009.218

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