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Supplementary information 2 PDPN expressions in ZK-1 cells in RNAi experiments: By siRNA, the PDPN gene expression levels of ZK-1 cells (siPDPN cells) were suppressed at least for 120 hrs (a). The suppressed PDPN expression level in siPDPN cells was also confirmed by immunofluorescence (red color) at 72 hrs (b).