1 / 3

Investigating the Role of S100A7 and EGF in T47D Cell Migration and Invasion

This study explores the impact of S100A7 and EGF on cell migration and invasion in T47D cells. We present supplementary figures demonstrating cell migration metrics under various conditions, including S100A7 expression and EGF stimulation. Key signaling pathways involving EGFR, LIMK-1/2, Rac-1, and NF-KB are analyzed, with a focus on how S100A7 interacts with ERα to regulate MMP-9 activity. Findings suggest that S100A7 plays a crucial role in invasive behavior, providing insights into cancer cell motility mechanisms.

ofira
Télécharger la présentation

Investigating the Role of S100A7 and EGF in T47D Cell Migration and Invasion

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. a b 120 T47D 100 80 % Cell migration 60 * 40 20 0 Vector S100A7 SCP6 % Cell migration * Supplementary Fig. 1

  2. T47D 30 Vector S100A7 20 % Invasion * 10 * 0 -EGF +EGF Supplementary Fig. 2

  3. EGF EGFR LIMK-1/2 Active Rac-1 GTP S100A7-ERα- Migration p-Cofilin F-actin G-actin N p-p65-NF-KB ATP NF-KB binding site S100A7-ERα+ MMP-9 Invasion LIMK-1/2 MMP-9 Active Rac-1 MMP-9 Invasion Migration Supplementary Fig. 3

More Related