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Supplementary Figure S1

Supplementary Figure S1. a. b. Asyn. Noco. Asyn. Noco. DMSO. DMSO. XAV939. XAV939. -. +. -. +. PPase. TNKS1. 150. TNKS1. 150. IP ( α TNKS1). PAR. IP ( α TNKS1). PAR. 150. 150. PTTG1. Cyclin B1. Actin. Actin. Supplementary Figure S2. shLuc. shPlk1. pHA. pHA-Plk1.

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Supplementary Figure S1

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  1. SupplementaryFigure S1 a b Asyn Noco Asyn Noco DMSO DMSO XAV939 XAV939 - + - + PPase TNKS1 150 TNKS1 150 IP (αTNKS1) PAR IP (αTNKS1) PAR 150 150 PTTG1 Cyclin B1 Actin Actin

  2. SupplementaryFigure S2 shLuc shPlk1 pHA pHA-Plk1 Flag-TNKS1 Flag HA-Plk1 Endogenous Plk1 Plk1 Myc-TRF1 Myc RFP Actin

  3. SupplementaryFigure S3 a b shLuc shTNKS1 NuMA TNKS 1 TRF1 Plk1 Phospho-H3 Actin shLuc shTNKS1 c 15.7 Phosho-H3-positive cells (%) 3.9 shLuc shTNKS1

  4. Supplementary Figure S4 Plk1 TNKS1 DAPI Merge shLuc shTNKS1 Plk1 TNKS1 DAPI Merge shLuc shTNKS1

  5. SupplementaryFigure S5 HeLa MRC-5 L-132 WI-26 NCI-H1299 Calu-3 HCC-1833 HCC-2108 A549 HCC-1171 SK-MES-1 lung cells hyperphosphorylation TNKS1 PlK1 Actin

  6. SupplementaryFigure S6 a b His-TNKS1 GST-TRF1 GST-TRF1 - - + + GST GST-TRF1 Plk1 Input (1/5) Input (1/5) - - + + GST GST - - + + TNKS1 TRF1 Phospho-Ser + + + + + + - + - - + + TNKS1 Phospho-Ser TRF1 His-TNKS1 Plk1

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