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Investigation of Gene Silencing Effects on Cancer Cell Lines and Signaling Pathways

This study examines the impact of gene silencing on various cancer cell lines, including A549, SW1573, H2009, and others. Multiple supplementary figures illustrate the effects of siRNA treatments targeting RALA and RALB, along with the analysis of protein expression levels via Western blotting, focusing on key proteins such as α-Tubulin, β-Actin, AKT, and ERK. The results highlight the modulation of signaling pathways that could inform future therapeutic strategies in cancer treatment.

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Investigation of Gene Silencing Effects on Cancer Cell Lines and Signaling Pathways

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  1. Supp Figure 1 A B C D

  2. Supp Figure 2 A B D C

  3. Supp Figure 3 A B C

  4. Supp Figure 4 A B

  5. Supp Figure 5 H2228 HCC4006 H322 H1703 Calu-3 H292 siRALA+B siRALB siRALB siRALB siRALB siRALB siRALA siRALA siRALA siRALA siRALA siRALA+B siRALA+B siRALA+B siRALA+B siRALA+B siRALB siRALA siCTL siCTL siCTL siCTL siCTL siCTL RALA RALB α-Tubulin H2009 H358 H157 A549 SW1573 H2122 siRALB siRALA siRALA+B siRALA+B siRALB siRALB siRALB siRALA+B siRALB siRALA siRALA siRALA siRALA siRALA+B siRALA+B siRALA+B siRALB siRALA siCTL siCTL siCTL siCTL siCTL siCTL RALA RALB α -Tubulin

  6. Supp Figure 6 siCTL siRALA II siRALBII A RALA β-Actin siCTL siRALA II siRALB II RALB β-Actin siCTL siRALB II siRALA II B 3±1.7* 9.5±0.9* 89.4±3.2

  7. SW1573* Calu6* H2009* H358* H2122* H460* H157* A549* H292 H2228 H1703 H4006 Calu3 H322 Supp Figure 7 pAKT Se(308) Thr(473) AKT pERK ERK

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